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The Double Marker Test is a prenatal screening test performed during the first trimester of pregnancy, usually between 9 to 13 weeks. It helps assess the risk of genetic abnormalities in the fetus by measuring the levels of free Beta-hCG (Human Chorionic Gonadotropin) and PAPP-A (Pregnancy-Associated Plasma Protein-A) in the mother's blood. These markers provide insights into the likelihood of chromosomal disorders such as Down syndrome (Trisomy 21) and Edwards syndrome (Trisomy 18). This test is especially recommended for women over 35 years of age, those with a family history of genetic conditions, or those who have undergone IVF treatments. The Double Marker Test is often combined with an NT scan (Nuchal Translucency scan) for better accuracy. A simple blood sample is required for the test, and the results are interpreted along with maternal factors such as age, medical history, and ultrasound findings. Since this is a screening test and not a diagnostic test, abnormal results may lead to further confirmatory tests like Chorionic Villus Sampling (CVS) or Amniocentesis. Early detection through this test helps in informed decision-making and better pregnancy management.